PHYSICAL CHARACTERISTICS Copper-64 ( 64Cu ) ▖Radioactive half-life: 12.7 h ▖Main types of radiation emitted: b- and b+ Copper-67 ( 67Cu ) ▖Radioactive half-life: 2.6 d ▖Main types of radiation emitted: b+ and g SOURCES OF EXPOSURE ▖64Cu: nuclear medicine 67 Cu Copper 64 Cu Copper INTERNAL CONTAMINATION MEASUREMENT J Urine bioassay J Faeces bioassay J In vivo measurement Copper EMERGENCY TREATMENT Two treatments are possible. Sodium calcium edetate PRESENTATION SODIUM CALCIUM EDETATE SERB®, 50 mg/ml, solution for IV injection. 10 ml vials containing 500 mg of Sodium calcium edetate. DOSAGE Adults: 2 vials by infusion in 250 ml of saline. Children according to their weight (as a guideline only): Weight Daily dosage < 18 kg ½ vial 18 to 30 kg ½ vial to 1 vial ≥ 30 kg 1 vial Penicillamine PRESENTATION TROLOVOL® (ERENPHARMA), tablet containing 0.3 g of Penicillamine. DOSAGE Adults: 3 to 5 tablets per day in 2 to 3 doses. Children: 20 mg/kg/d of body weight, divided into 2 or 3 doses. CONTRAINDICATIONS ▖Haematuric and protein nephropathies. ▖Severe haematological disorders. ▖Lupus erythematosus, myasthenia gravis, severe dermatoses. ▖Allergy to penicillins and cephalosporins, due to the possibility in certain people of cross-allergenicity between the beta-lactamines and D-penicillamine. ▖History of severe accidents (medullar aplasia, pemphigus, myasthenia gravis) caused by thiol derivatives (tiopronine, pyritinol). EXPOSURE RISK ▖Irradiation ++ 67Cu and 64Cu ▖External contamination +++ ▖Internal contamination + french-nuclear-safety.fr/dosimetric-references DOSE COEFFICIENT REFERENCE Effective committed dose per becquerel incorporated, taken from the Order mentioned in Article R. 1333-24 of the Public Health Code: RADIONUCLIDE HANDBOOK • Emergency treatment of internal contamination RH 16
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