french-nuclear-safety.fr/dosimetric-references PHYSICAL CHARACTERISTICS Indium-111 ( 111In ) ▖Radioactive half-life: 2.8 d ▖Main types of radiation emitted: g Indium-115m ( 115mIn ) ▖Radioactive half-life: 4.5 h ▖Main types of radiation emitted: e- and g SOURCES OF EXPOSURE ▖111In: nuclear medicine (diagnosis) 115m In Indium 111 In Indium INTERNAL CONTAMINATION MEASUREMENT J Urine bioassay J Faeces bioassay J In vivo measurement Indium EMERGENCY TREATMENT FIRST-LINE TREATMENT Prussian Blue (Iron ferrocyanide) PRESENTATION RADIOGARDASE® 500 mg capsules (SERB). DOSAGE Persons > 12 years: 1 g, 3 times a day, i.e. 3 g/d. Children (2 to 12 years): 0.5 g, 3 times a day, i.e. 1.5 g/d. Children (< 2 years): no data being available, the administration of Prussian Blue must be evaluated with respect to the risks involved. The capsules must be swallowed with a drink or with foodstuffs; food intake speeds up biliary secretion and the enterohepatic cycle. With patients who have difficulty swallowing, the capsules can be opened and their content mixed with the food or a liquid (e.g. a mannitol solution). SECOND-LINE TREATMENT Pentetate calcium trisodium No demonstrated clinical effectiveness. If the victim is unconscious (oral route not available), can be used as a second-line treatment due to its good tolerance profile. PRESENTATION Ca-DTPA 250 mg/ml, injectable solution. 4 ml vial (PCA – Central Pharmacy of the Armed Forces). DOSAGE Persons > 12 years: slow IV injection or infusion in 15 min of a half-vial of Ca-DTPA (i.e. 0.5 g), diluted in 100 to 200 ml of isotonic saline solution or 5% glucose solution, without exceeding 1 g/d. Children (< 12 years): slow IV injection or infusion 14 mg/kg, without exceeding 0.5 g/d. TREATMENTS COMPLEMENTARY TO INTRAVENOUS ADMINISTRATION ▪ Pulmonary contamination Adults – Children (to be used with caution): 1 g in a single administration by inhalation – nebulisation only (spray mist, 50/50 dilution of a 4 ml vial in sterile or saline water). ▪ Contaminated wounds Pour one or more vials over the wound. IRSN-INRS radionuclide sheet: Radiation protection: Radionucléides. Indium-111 (irsn.fr). to find more EXPOSURE RISK ▖Irradiation ++ ▖External contamination ++ ▖Internal contamination ++ DOSE COEFFICIENT REFERENCE Effective committed dose per becquerel incorporated, taken from the Order mentioned in Article R. 1333-24 of the Public Health Code: RADIONUCLIDE HANDBOOK • Emergency treatment of internal contamination RH 23
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