Medical response in a nuclear or radiological emergency

PHYSICAL CHARACTERISTICS Iodine-123 ( 123I ) ▖Radioactive half-life: 13.2 h ▖Main types of radiation emitted: X and g 132 I Iodine 131 I Iodine INTERNAL CONTAMINATION MEASUREMENT J Urine bioassay J Faeces bioassay J In vivo measurement: Thyroid in vivo measurement Iodine 125 I Iodine 123 I Iodine SOURCES OF EXPOSURE ▖131I and 132I: nuclear reactors (fission products) ▖123I, 125I and 131I: nuclear medicine ▖125I: radioimmunology Iodine-125 ( 125I ) ▖Radioactive half-life: 60 d ▖Main types of radiation emitted: e- and X Iodine-131 ( 131I ) ▖Radioactive half-life: 8 d ▖Main types of radiation emitted: b- and g Iodine-132 ( 132I ) ▖Radioactive half-life: 2.3 h ▖Main types of radiation emitted: b- and g EMERGENCY TREATMENT FIRST-LINE TREATMENT Potassium iodide PRESENTATION Potassium iodide, 65 mg tablets (PCA – Central Pharmacy of the Armed Forces). DOSAGE Persons > 12 years: (including pregnant women): 2 tablets. Children (3 to 12 years): 1 tablet. Children (1 month to 3 years): ½ tablet (may be dissolved in water, milk or fruit juice). Newborns (< 1 month): 16 mg, i.e. ¼ tablet. To be effective, the iodine tablet must be taken ideally a few hours before exposure to the radioactive particles and gases and within 8 hours after exposure at the latest. In the event of a nuclear or radiological accident, the tablets pre-distributed to the public must only be taken when formally instructed to do so by the competent authorities (Prefect or high command in a military environments). The treatment must not be renewed unless instructed to do so by the competent authorities. SECOND-LINE TREATMENT 1% iodine solution (Lugol's iodine) Lugol's iodine can be used as an alternative to Potassium iodide tablets when the latter are not available. PRESENTATION LUGOL's iodine (1% potassium iodide – iodine solution) oral drops, prepared by pharmacist. DOSAGE Persons > 12 years (> 12 years): 80 drops. Children (3 to 12 years): 40 drops. Children (< 3 years): 20 drops (Codex dropper). IRSN-INRS radionuclide sheet: Radiation protection: radionuclides. Iodine-123 (irsn.fr), Radiation protection: radionuclides. Iodine-125 ( irsn.fr), Radiation protection: radionuclides. Iodine-131 ( irsn.fr). to find more EXPOSURE RISK ▖Irradiation ++ ▖External contamination ++ ▖Internal contamination +++ DOSE COEFFICIENT REFERENCE Effective committed dose per becquerel incorporated, taken from the Order mentioned in Article R. 1333-24 of the Public Health Code: french-nuclear-safety.fr/dosimetric-references RADIONUCLIDE HANDBOOK • Emergency treatment of internal contamination RH 24

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