french-nuclear-safety.fr/dosimetric-references EMERGENCY TREATMENT Pentetate calcium trisodium No demonstrated clinical effectiveness, but usable due to its good tolerance profile. PRESENTATION Ca-DTPA 250 mg/ml, injectable solution. 4 ml vial (PCA – Central Pharmacy of the Armed Forces). DOSAGE Persons > 12 years: slow IV injection or infusion in 15 min of a half-vial of Ca-DTPA (i.e. 0.5 g), diluted in 100 to 200 ml of isotonic saline solution or 5% glucose solution, without exceeding 1 g/d. Children (< 12 years): slow IV injection or infusion 14 mg/kg, without exceeding 0.5 g/d. TREATMENTS COMPLEMENTARY TO INTRAVENOUS ADMINISTRATION ▪ Pulmonary contamination Adults – Children (to be used with caution): 1 g in a single administration by inhalation – nebulisation only (spray mist, 50/50 dilution of a 4 ml vial in sterile or saline water). ▪ Contaminated wounds Pour one or more vials over the wound. PHYSICAL CHARACTERISTICS Lutetium-177 ( 177Lu ) ▖Radioactive half-life: 6.7 d ▖Main types of radiation emitted: b- and g SOURCES OF EXPOSURE ▖Nuclear medicine (therapy) 177 Lu Lutetium EXPOSURE RISK ▖Irradiation ++ ▖External contamination +++ ▖Internal contamination +++ INTERNAL CONTAMINATION MEASUREMENT J Urine bioassay J In vivo measurement Lutetium DOSE COEFFICIENT REFERENCE Effective committed dose per becquerel incorporated, taken from the Order mentioned in Article R. 1333-24 of the Public Health Code: RADIONUCLIDE HANDBOOK • Emergency treatment of internal contamination RH 29
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