french-nuclear-safety.fr/dosimetric-references PHYSICAL CHARACTERISTICS Nickel-63 ( 63Ni ) ▖Radioactive half-life: 100 years ▖Main types of radiation emitted: b- Nickel-65 ( 65Ni ) ▖Radioactive half-life: 2.5 h ▖Main types of radiation emitted: b- and g SOURCES OF EXPOSURE ▖Nuclear reactors (activation products) 65 Ni Nickel 63 Ni Nickel INTERNAL CONTAMINATION MEASUREMENT J Urine bioassay J Faeces bioassay J In vivo measurement Nickel EMERGENCY TREATMENT The use of Succimer is recommended for children. FIRST-LINE TREATMENT Succimer PRESENTATION SUCCICAPTAL® 100 mg capsules (SERB). DOSAGE Children (2 to 11 years), adolescents (12 to 17 years), adults: 10 mg/kg to be administered orally every 8 h (i.e. 30 mg/kg/d). In the adult, the dose of 1.80 g/d should generally not be exceeded. With children (< 6 years), the capsules can be opened (to ensure the right dosage) and the powder dissolved in a fruit compote, yoghurt or a drink in order to mask its unpleasant taste and smell. OR Sodium calcium edetate PRESENTATION SODIUM CALCIUM EDETATE SERB®, 50 mg/ml, solution for IV injection. 10 ml vials containing 500 mg of Sodium calcium edetate. DOSAGE Adults: 2 vials by infusion in 250 ml of saline. Children according to their weight (as a guideline only): Weight Daily dosage < 18 kg ½ vial 18 to 30 kg ½ vial to 1 vial ≥ 30 kg 1 vial SECOND-LINE TREATMENT Dimercaprol PRESENTATION B.A.L. solution for intramuscular injection (SERB). 2 ml vials containing 200 mg. DOSAGE 3 mg/kg body weight and strictly by IM injection, 1 injection every 4 h. As with all non-aqueous injectable solutions, administer using a glass syringe. CONTRAINDICATIONS ▖Special warning in case of renal impairment. ▖Allergy to peanuts. DOSE COEFFICIENT REFERENCE Effective committed dose per becquerel incorporated, taken from the Order mentioned in Article R. 1333-24 of the Public Health Code: EXPOSURE RISK ▖Irradiation ++ 65Ni ▖External contamination ++ ▖Internal contamination ++ RADIONUCLIDE HANDBOOK • Emergency treatment of internal contamination RH 34
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