Medical response in a nuclear or radiological emergency

PHYSICAL CHARACTERISTICS Potassium-42 ( 42K ) ▖Radioactive half-life: 12.4 h ▖Main types of radiation emitted: b- and g Potassium-43 ( 43K ) ▖Radioactive half-life: 22.2 h ▖Main types of radiation emitted: b- and g SOURCES OF EXPOSURE ▖42K: nuclear medicine 43 K Potassium 42 K Potassium INTERNAL CONTAMINATION MEASUREMENT J Urine bioassay J In vivo measurement Potassium EMERGENCY TREATMENT Potassium chloride PRESENTATION LAVOISIER POTASSIUM CHLORIDE 10% (0.10 g/ml). A 20 ml vial contains 2 g of Potassium chloride. INDICATIONS Contamination by ingestion. DOSAGE To be administered by oral route. While monitoring the plasma potassium concentration in hospital: Weight Dosage Quantity of potassium in mmol/kg 0 to 10 kg 1 vial 2.7 10 to 20 kg 2 vials 2.7 20 to 30 kg 3 vials 2.7 30 to 40 kg 3 vials 2.0 40 to 50 kg 4 vials 2.1 > 50 kg 5 vials 2.2 Risk of hyperkalaemia (excessively high potassium concentration) if more than 2 mmol/kg of potassium is administered in the adult and more than 3 mmol/kg of potassium in the child. The dosage is valid for vials containing 20 ml of 10% Potassium chloride. Other formats are sold in the form of: ▖LAVOISIER POTASSIUM CHLORIDE 10% (0.10 g/ml), 1 vial of 10 ml: the dosage must be increased by 2 (doubled). ▖LAVOISIER POTASSIUM CHLORIDE 20% (0.10 g/ml), 1 vial of 10 ml: the dosage remains the same. ▖LAVOISIER POTASSIUM CHLORIDE 20% (0.10 g/ml), 1 vial of 20 ml: the dosage must be reduced by 2 (halved). CONTRAINDICATIONS The administration of this medication is contraindicated in cases of hyperkalaemia or any situation that could lead to hyperkalaemia (severe renal impairment, acute adrenal insufficiency, decompensated metabolic acidosis). DOSE COEFFICIENT REFERENCE Effective committed dose per becquerel incorporated, taken from the Order mentioned in Article R. 1333-24 of the Public Health Code: french-nuclear-safety.fr/dosimetric-references EXPOSURE RISK ▖Irradiation ++ ▖External contamination ++ ▖Internal contamination ++ RADIONUCLIDE HANDBOOK • Emergency treatment of internal contamination RH 38

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