Following the approval of ASN Resolution 2014-DC-0463 of 23 October 2014 setting the minimum technical design, operating and maintenance rules for in vivo nuclear medicine facilities, by the Order of 16 January 2015, this document aims to present in detail the articles of the abovementioned Resolution and this revision provides the opportunity to gives some details further to operating experience feedback and the IRSN referrals on different points.